THE CHANG LAB

Publication Archive


  1. Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
    In Young Hwang,*, Elvin Koh,*, Adison Wong, John C. March, William E. Bentley, Yung Seng Lee, and Matthew Wook Chang
    Nature Communications, 2017 8:15028

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  2. Designer probiotics for the prevention and treatment of human diseases
    Koon Jiew Chua1, Wee Chiew Kwok, Nikhil Aggarwal, Tao Sun, and Matthew Wook Chang
    Current Opinion in Chemical Biology 2017, 40C:xx–yy

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  3. Applying the design-build-test paradigm in microbiome engineering
    Hoang Long Pham,*, Chun Loong Ho,*, Adison Wong,*, Yung Seng Lee, and Matthew Wook Chang
    Current Opinion in Biotechnology 2017, 48:85–93

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  4. The Fungal Mycobiome and Its Interaction with Gut Bacteria in the Host
    Qi Hui Sam , MatthewWook Chang, and Louis Yi Ann Chai
    International Journal of Molecular Sciences. 2017, 18, 330

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  5. Microbiome engineering: Current applications and its future
    Jee Loon Foo2, Hua Ling, Yung Seng Lee, and Matthew Wook Chang*
    Biotechnology Journal. 2017, 12, 1600099

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  6. Synthetic Biology in Asia: New Kids on the Block
    Matthew Wook Chang*
    ACS Synthetic Biology. 10.1021/acssynbio.6b00327

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  7. Genetic Engineering of an Unconventional Yeast for Renewable Biofuel and Biochemical Production
    Ai-Qun Yu, Nina Pratomo, Tee-Kheang Ng, Hua Ling, Han-Saem Cho, Susanna Su Jan Leong, Matthew Wook Chang*
    Journal of Visualized Experiments. doi:10.3791/54371

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  8. Reprogrammable microbial cell-based therapeutics againstantibiotic-resistant bacteria
    In Young Hwanga,b, Elvin Kohb,c, Hye Rim Kima,b, Wen Shan Yewa, Matthew Wook Chang*
    Drug Resistance Updates. 27 (2016) 59–71

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  9. A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production
    Lo T, Chng SH, Teo WS, Cho HS, Chang MW*
    Cell Systems. 3:133-143. (2016)

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  10. Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids
    Yu A, Pratomo NK, Foo JL, Leong SSJ, Chang MW*
    Metabolic Engineering. 34:36-43. (2016)

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  11. Whole-cell biocatalytic and de novo production of alkanes from free fatty acids in Saccharomyces cerevisiae
    Foo JL, Susanto AV, Keasling JD, Leong SSJ, Chang MW*
    Biotechnology and Bioengineering. 114:232-237. (2016).

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  12. Engineering transcription factors to improve tolerance against alkane biofuels in Saccharomyces cerevisiae
    Ling H, Pratomo NK, Teo WS, Liu R, Leong SSJ, Chang MW*
    Biotechnology for Biofuels. 8:231. (2015)

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  13. Combinatorial metabolic engineering of Saccharomyces cerevisiae for terminal alkene production
    Chen BB, Lee DY, Chang MW*
    Metabolic Engineering. 31:53-61. (2015)

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  14. Engineering Saccharomyces cerevisiae to produce odd chain-length fatty alcohols
    Jin Z, Wong CK, Foo JL, Ng J, Cao YX, Chang MW*, Yuan YJ
    Biotechnology and Bioengineering. 113:842-51. (2015)

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  15. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel
    Teo W, Ling H, Yu AQ, Chang MW*
    Biotechnology for Biofuels. 8:177. (2015)

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  16. Matrix-immobilized yeast for large-scale production of recombinant human lactoferrin
    Ho CL, Hwang IY, Loh K and Chang MW*
    MedChemComm. 6:486 – 491. (2015)

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  17. Production of fatty acid-derived valuable chemicals in synthetic microbes
    Yu AQ, Pratomo Juwono NK, Leong SSJ and Chang MW*
    Frontiers in Bioengineering and Biotechnology. 2:78 (2014)

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  18. Bacterial XylRs and synthetic promoters function as genetically encoded xylose biosensors in Saccharomyces cerevisiae
    Teo W and Chang MW*
    Biotechnology Journal. 10:315-322. (2015)

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  19. Microbial tolerance engineering toward biochemical production: from lignocellulose to products
    Ling H, Teo W, Chen B, Leong SSJ, Chang MW*
    Current Opinion in Biotechnology. 29:99-106. (2014)

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  20. Site specific immobilization of a potent antimicrobial peptide onto silicone catheters: evaluation against urinary tract infection pathogens
    Mishra B, Basu A, Chua RRY, Saravanan R, Tambyah PA, Ho B, Chang MW, Leong SSJ
    Journal of Materials Chemistry. 2:1706-1716. (2014)

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  21. Reprogramming microbes to be a pathogen-seeking killer
    Hwang IY, Tan MH, Koh E, Ho CL, Poh CL, and Chang MW*
    ACS Synthetic Biology. 3:228-237. (2014)

    Featured in The Economist, Nature News, Medical News, Science World Report, Science Daily, Vaccine News Daily, Food Quality News, MedCity News; Press release by American Chemical Society
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  22. Development and characterization of AND-gate dynamic controllers with a modular synthetic core promoter in Saccharomyces cerevisiae
    Teo W, Chang MW*
    Biotechnology and Bioengineering. 111:144-151. (2014)

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  23. Therapeutic microbes for infectious disease
    Wong CK, Tan MH, Rasouliha B, Hwang IY, Ling H, Poh CL and Chang MW*
    Methods in Molecular Biology. 1151:117-133. (2014)

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  24. A predicted immunity protein confers resistance to pyocin S5 on a sensitive strain of Pseudomonas aeruginosa
    Rasouliha B, Ling H, Ho CL, Chang MW*
    ChemBioChem. 14:2444-2446.47. (2013)

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  25. Transcriptome response to alkane biofuels in Saccharomyces cerevisiae: identification of efflux pumps involved in alkane tolerance
    Ling H, Chen BB, Kang A, Lee J, Chang MW*
    Biotechnology for Biofuels. 6:95. (2013)

    Featured in Biofuels International
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  26. Bacterial FadR and synthetic promoters function as modular fatty acid sensor- regulators in Saccharomyces cerevisiae
    Teo W, Hee KS, Chang MW*
    Engineering in Life Sciences. 13:456-463. (2013)

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  27. Designing a synthetic genetic circuit that enables cell density-dependent auto-regulatory lysis for macromolecule release
    Lo T, Tan MH, Hwang IY, Chang MW*
    Chemical Engineering Science. 103:29-35. (2013)

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  28. Microbial engineering strategies to improve cell viability for biochemical production
    Lo T, Teo WS, Ling H, Chen BB, Kang A, Chang MW*
    Biotechnology Advances. 31:903-914. (2013)

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  29. Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae
    Chen BB, Ling H, Chang MW*
    Biotechnology for Biofuels. 6:21. (2013)

    Featured in the Global Knowledge Center on Crop Biotechnology
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  30. Characterization of a quorum sensing device for synthetic biology design: experimental and modeling validation
    Saeidi N, Chang MW, and Poh CL
    Chemical Engineering Science. 103:91-99. (2013)

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  31. Systems-level characterization and engineering of oxidative stress tolerance in Escherichia coli under anaerobic condition
    Kang A, Tan MH, Ling H, Chang MW*
    Molecular BioSystems. 9:285-295. (2013)

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  32. Hildebrand solubility parameters of ionic liquids: effects of ionic liquid type, temperature and DMA fraction in ionic liquid
    Weerachanchai P, Chen Z, Leong SSJ, Chang MW, Lee JM
    Chemical Engineering Journal. 213:356-362. (2012)

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  33. Cefalexin-immobilized multi-walled carbon nanotubes show strong antimicrobial and anti-adhesion properties
    Qi X, Poernomo G, Xu R, Chang MW*
    Chemical Engineering Science. 84:552-556. (2012)

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  34. Systems-level analysis of Escherichia coli response to silver nanoparticles: The roles of anaerobic respiration in microbial resistance
    Du H, Lo T, Sitompul J, and Chang MW*
    Biochemical and Biophysical Research Communications. 424:657-662. (2012)

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  35. Improvement of biomass properties by pretreatment with ionic liquids for bioconversion process
    Weerachanchai P, Leong SSJ, Chang MW, Ching CB, Lee JM
    Bioresource Technology. 111:453-459. (2012)

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  36. Identification and reconstitution of genetic regulatory networks for improved microbial tolerance to isooctane
    Kang A, Chang MW*
    Molecular BioSystems. 8:1350-1358. (2012)

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  37. The imminent role of protein engineering in synthetic biology
    Foo JL, Ching CB, Chang MW, Leong SSJ
    Biotechnology Advances. 30:541-549. (2012)

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  38. Hollow fiber membrane decorated with Ag/MWNTs: Towards effective water disinfection and biofouling control
    Gunawan P, Guan C, Song X; Zhang Q, Leong S, Tang C, Chen Y, Chan-Park M, Chang MW, Wang K, Xu R
    ACS Nano. 5:10033-10040. (2011)

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  39. The roles of lipid in anti-biofilm efficacy of lipid–polymer hybrid nanoparticles encapsulating antibiotics
    Cheow WS, Chang MW, Hadinoto K
    Colloids and Surfaces A: Physicochemical and Engineering Aspects. 389: 158-165. (2011)

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  40. Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen
    Saeidi N, Wong CK, Lo T, Nguyen HX, Ling H, Leong SSJ, Poh CL, and Chang MW*
    Molecular Systems Biology. 7:521. (2011)

    Highlighted in Nature Reviews Genetics 9:699, and Nature Reviews Microbiology 12:668. This paper was reported by over 70 news media agencies worldwide, such as Reuters, CBS News, Fox News, Chicago Tribune, Australia Broadcasting Corporation News, Nature, Science, Yahoo News, The Scientist, Discover Magazine, International Business Times, and National Geographic. Locally, this work has been selected as one of the top 10 discoveries in 2011 by Straits Times, and featured by most local news agencies including Channel News Asia.
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  41. Covalent immobilization of nisin on multi-walled carbon nanotubes: superior antimicrobial and anti-biofilm properties
    Qi X, Poernomo G, Wang K, Chen Y, Chan-Park MB, Xu R, Chang MW*
    Nanoscale. 3:1874-1880. (2011)

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  42. Targeting FK506 binding proteins to fight malarial and bacterial infections: Current advances and future perspectives
    Bharatham N, Chang MW, Yoon HS
    Current Medicinal Chemistry. 18:1874-1889. (2011)

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  43. A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine
    Zhou C, Peng L, Qi X, Lamrani M, Chang MW*, Leong SS, Chan-Park MB
    Biomaterials. 32:2704-2712. (2011)

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  44. A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability
    Li P, Poon YF, Li W, Zhu HY, Yeap SH, Cao Y, Qi X, Zhou C, Lamrani M, Beuerman RW, Kang ET, Mu Y, Li CM, Chang MW, Leong SS, and Chan-Park MB
    Nature Materials. 10:149-156. (2011)

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  45. Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells
    Choi YH, Park CH, Kim W, Ling H, Kang A, Chang MW, Im SK, Jeong HW, Kong YY, Kim KT
    PLoS One. 5:e15254. (2010)

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  46. The absence of the luxS gene increases swimming motility and flagella synthesis in Escherichia coli K12
    Ling H, Kang A, Tan MH, Qiao B, and Chang MW*
    Biochemical and Biophysical Research Communications. 401:521-526. (2010)

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  47. A simple and effective plating method to screen polycyclic aromatic hydrocarbon-degrading bacteria under various redox conditions
    Um Y, Chang MW, and Holoman TP
    Applied Microbiology and Biotechnology. 88:291-297. (2010)

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  48. iTRAQ-coupled 2-D LC-MS/MS analysis of protein profile in Escherichia coli incubated with human Neutrophil Peptide 1 – Potential in Antimicrobial Strategy
    Zhou Y, Lamrani M, Chan-Park MB, Leong S, Chang MW, and Chen WN
    Rapid Communications in Mass Spectrometry. 24:2787-2790. (2010)

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  49. Novel short antibacterial and antifungal peptides with low cytotoxicity: efficacy and action mechanisms
    Qi X, Zhou C, Li P, Xu W, Cao Y, Ling H, Chen WN, Li CM, Xu R, Lamrani M, Mu Y, Leong S, Chang MW*, and Chan-Park MB
    Biochemical and Biophysical Research Communications. 398:594-600. (2010)

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  50. Antibacterial efficacy of inhalable Levofloxacin-loaded polymeric nanoparticles against E. coli biofilm cells: The effect of antibiotic release profile
    Cheow WS, Chang MW, Hadinoto K
    Pharmaceutical Research. 27:1597-1609. (2010)

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  51. A predicted S-type pyocin shows a bactericidal activity against clinical Pseudomonas aeruginosa isolates through membrane damage
    Ling H, Saedi N, Rasouliha BH, and Chang MW*
    FEBS Letters. 584:3354-3358. (2010)

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  52. High potency and broad-spectrum antimicrobial peptides synthesized via ring-opening polymerization of alpha-aminoacid-N-carboxyanhydrides
    Zhou C, Qi X, Li P, Chen WN, Lamrani M, Chang MW, Leong S and Chan-Park MB
    Biomacromolecules. 11:60-67. (2010)

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  53. Antibacterial efficacy of inhalable antibiotic-encapsulated biodegradable polymeric nanoparticles against E. coli biofilm cells
    Cheow WS, Chang MW, and Hadinoto K.
    Journal of Biomedical Nanotechnology. 6:1-13. (2010)


  54. Sharper and faster “Nano Darts” kill more bacteria: a study of antibacterial activity of individually dispersed pristine single-walled carbon nanotube
    Liu S, Wei L, Hao L, Fang N, Chang MW, Xu R, Yang Y, and Chen Y
    ACS Nano. 3:3891-3902. (2009)

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  55. A time-course transcriptome analysis of Escherichia coli with direct electrochemistry behavior in microbial fuel cells
    Qiao Y, Li CM, Lu Z, Ling H, Kang A and Chang MW*
    Chemical Communications 41:6183-6185

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  56. Strain improvement and process development for biobutanol production
    Kharkwal S, Karimi IA, Chang MW, and Lee DY
    Recent Patents on Biotechnology 3:202-210. (2009)

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  57. Deposition of Silver Nanoparticles on Multiwalled Carbon Nanotubes Grafted with Hyperbranched Poly(amidoamine) and Their Antimicrobial Effects
    Yuan W, Jiang G, Jianfei C, Xiaobao Q, Xu R, Chang MW, Chen Y, Lim SY, Dai J, and Chan-Park MB
    Journal of Physical Chemistry C 112:18754-18759. (2008)

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  58. Molecular characterization of surfactant-driven microbial community changes in anaerobic phenanthrene-degrading cultures under methanogenic conditions
    Chang MW*, Holoman TP, and Yi H
    Biotechnology Letters 30:1595-1601. (2008)

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  59. Microarray analysis of toxicogenomic effects of triclosan on Staphylococcus aureus
    Jang H, Chang MW, Toghrol F, and Bentley WE
    Applied Microbiology and Biotechnology 78:695-707. (2008)

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  60. Toxicogenomic response to chlorination includes induction of major virulence genes in Staphylococcus aureus
    Chang MW, Toghrol F, and Bentley WE
    Environmental Science and Technology 41:7570-7575. (2007)

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  61. Comparative global transcription analysis of sodium hypochlorite, peracetic acid, and hydrogen peroxide in Pseudomonas aeruginosa
    Small D, Chang W, Toghrol F, and Bentley WE
    Applied Microbiology and Biotechnology 76:1093-1105. (2007)

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  62. Toxicogenomic analysis of sodium hypochlorite antimicrobial mechanisms in Pseudomonas aeruginosa
    Small D, Chang W, Toghrol F, and Bentley WE
    Applied Microbiology and Biotechnology 74:176-185. (2007)

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  63. Toxicogenomic response of Staphylococcus aureus to peracetic acid
    Chang W, Toghrol F, and Bentley WE
    Environmental Science and Technology 40:5124-5131. (2006)

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  64. Polycyclic aromatic hydrocarbon (PAH) degradation coupled to methanogenesis
    Chang W*, Um Y, and Holoman TP
    Biotechnology Letters 28:425-430. (2006)

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  65. Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide
    Chang W, Small D, Toghrol F, and Bentley WE
    Journal of Bacteriology 184:1648-1659. (2006)

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  66. Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide
    Chang W, Small D, Toghrol F, and Bentley WE
    BMC Genomics 6:115. (2005)

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  67. Microarray analysis of toxicogenomic effects of peracetic acid on Pseudomonas aeruginosa
    Chang W, Small D, Toghrol F, and Bentley WE
    Environmental Science and Technology 39:5893-5899. (2005)

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  68. Molecular characterization of anaerobic microbial communities from benzene-degrading sediments under methanogenic conditions
    Chang W, Um Y, and Holoman TP
    Biotechnology Progress 21:1789-1794. (2005)

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  69. Molecular characterization of polycyclic aromatic hydrocarbon (PAH)-degrading methanogenic communities
    Chang W, Um Y, Hoffman B, and Holoman TP
    Biotechnology Progress 21:682-688. (2005)

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  70. Anaerobic polycyclic aromatic hydrocarbon (PAH)-degrading enrichment cultures under methanogenic conditions
    Chang W, Jones T, and Holoman TP
    Bioremediation of Recalcitrant Organic Compounds, Battelle Press, Columbus, Ohio. p. 205-210. (2001)