Leading Solutions through Innovation in Synthetic Biology
Sustainable bioproduction offers the versatility to synthesize a wide range of chemicals and materials from renewable feedstocks by employing and improving enzymes or biocatalysts originating from the nature. In Chang lab, we aim to engineer microbial hosts, enzymes and pathways to develop novel bioprocesses for the production of value-added compounds in a sustainable manner.
Synthetic genomics is a branch of synthetic biology that aims to customize organisms by redesigning their genomic sequences to confer novel functionalities. In Chang lab, we aim to employ synthetic genomics in microbes and mammalian cells to develop genome editing tools, gain deeper understanding of biological functions and create biological systems for biotechnological applications.
The microbiome is the collection of microbes and their genomes in a particular environment. The presence or absence of certain microbial communities in the body has been implicated in a variety of human health conditions. In Chang lab, we aim to develop novel therapeutic modalities that can rewire host–microbiome interactions such as host metabolism and immunity for disease prevention and treatment.
Our Funding Partners
We are an interdisciplinary team of graduate and undergraduate students, scientists, engineers, clinicians and visiting scholars from diverse backgrounds. Since 2007, we have been aspiring to be a leading research group in synthetic biology, occupying a central role in the dissemination of engineering and biological knowledge for the creation of technological solutions for global challenges. We pride ourselves in building new engineering biology knowledge and solutions, educating the next generation of synthetic biologists and serving the communities in Singapore and beyond. In Singapore, we led the establishment of NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Wilmar-NUS Corporate Laboratory ([email protected]) and Singapore Consortium for Synthetic Biology (SINERGY). Globally, we played a key role in founding the Global Biofoundries Alliance (GBA) and the Asian Synthetic Biology Association (ASBA). Our lab alumni include over 50 undergraduate and high school students, 20 Ph.D. students and 40 research scientists, many now in leadership roles in academia, government and industry.
UNDERGRADUATES AND INTERNS
Our Latest Publications
FELICX: A robust nucleic acid detection method using flap endonuclease and CRISPR-Cas12
Aggarwal N, Liang Y, Foo JL, Ling H, Hwang IY, Chang MW*
Biosensors and Bioelectronics https://doi.org/10.1016/j.bios.2022.115002
Microbiome and human health: current understanding, engineering, and enabling technologies
Aggarwal N, Kitano S, Puah GRY, Kittelmann S, Hwang IY, Chang MW*
Chemical Reviews https://doi.org/10.1021/acs.chemrev.2c00431
Synthetic biology meets machine learning
Sieow BFL, De Sotto R, Seet ZRD, Hwang IY, Chang MW*
Methods in Molecular Biology https://doi.org/10.1007/978-1-0716-2617-7_2
Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism
Koh E, Hwang IY, Lee HL, De Sotto R, Lee JWJ, Lee YS, March JC, Chang MW
Nature Communications https://doi.org/10.1038/s41467-022-31334-z
Get in Touch!
We are excited to work with brilliant minds beaming with fresh ideas and insights into the curious natural world we live in. If you care about this planet and want to make a difference to it, then please don’t hesitate to get in touch with us for exciting opportunities in Chang Lab.