+65 6601 2449 [email protected]


Leading Solutions through Innovation in Synthetic Biology


Our Research

Sustainable Bioproduction

Sustainable bioproduction offers the versatility to synthesize a wide range of chemicals and materials from renewable feedstocks by employing and improving enzymes or biocatalysts originating from the nature. In Chang lab, we aim to engineer microbial hosts, enzymes and pathways to develop novel bioprocesses for the production of value-added compounds in a sustainable manner.

Synthetic Genomics

Synthetic genomics is a branch of synthetic biology that aims to customize organisms by redesigning their genomic sequences to confer novel functionalities. In Chang lab, we aim to employ synthetic genomics in microbes and mammalian cells to develop genome editing tools, gain deeper understanding of biological functions and create biological systems for biotechnological applications.


The microbiome is the collection of microbes and their genomes in a particular environment. The presence or absence of certain microbial communities in the body has been implicated in a variety of human health conditions. In Chang lab, we aim to develop novel therapeutic modalities that can rewire host–microbiome interactions such as host metabolism and immunity for disease prevention and treatment.


Our Funding Partners


Our Story

We are an interdisciplinary team of graduate and undergraduate students, scientists, engineers, clinicians and visiting scholars from diverse backgrounds. Since 2007, we have been aspiring to be a leading research group in synthetic biology, occupying a central role in the dissemination of engineering and biological knowledge for the creation of technological solutions for global challenges. We pride ourselves in building new engineering biology knowledge and solutions, educating the next generation of synthetic biologists and serving the communities in Singapore and beyond. In Singapore, we led the establishment of NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Wilmar-NUS Corporate Laboratory ([email protected]) and Singapore Consortium for Synthetic Biology (SINERGY). Globally, we played a key role in founding the Global Biofoundries Alliance (GBA) and the Asian Synthetic Biology Association (ASBA). Our lab alumni include over 50 undergraduate and high school students, 20 Ph.D. students and 40 research scientists, many now in leadership roles in academia, government and industry.








Our Latest Publications

Mitochondrial engineering of Yarrowia lipolytica for sustainable production of α-bisabolene from waste cooking oil
Zhu K, Zhao B, Zhang Y, Kong J, Rong L, Liu S, Wang Y, Zhang C-Y, Xiao D, Foo JL, Yu A

ACS Sustainable Chemistry and Engineering https://doi.org/10.1021/acssuschemeng.2c03063


Principles in microbiome engineering
Chang MW

Wiley-VCH GmbH. https://doi.org/10.1002/9783527825462

Dominant negative TRAF3 variant with recurrent Mycobacterium abscessus infection and bronchiectasis
Liew MF, Lim HF, Liang MC, Lim I, Tan Z, Tan RYM, Sam QH, Soe WM, Tay SH, Xu S, Chang MW, Foo R, Soong TW, Ravikumar S, Chai LYA

Open Forum Infectious Diseases. https://doi.org/10.1093/ofid/ofac379

Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism

Koh E, Hwang IY, Lee HL, De Sotto R, Lee JWJ, Lee YS, March JC, Chang MW

Nature Communications https://doi.org/10.1038/s41467-022-31334-z

Engineered microbial systems for advanced drug delivery
Shen HS, Aggarwal N, Wun KS, Lee YS, Hwang IY, Chang MW*

Advanced Drug Delivery Reviews: 114364 (2022) https://doi.org/10.1016/j.addr.2022.114364

Potential use of microbial engineering in single-cell protein production
Balagurunathan B, Ling H, Choi WJ, Chang MW

Current Opinion in Biotechnology https://doi.org/10.1016/j.copbio.2022.102740

Design and fabrication of field-deployable microbial biosensing device
Pham HL, Ling H, Chang MW

Current Opinion in Biotechnology https://doi.org/10.1016/j.copbio.2022.102731

Living Building Blocks
Miyake R, Ling H, Foo JL, Fugono N, Chang MW

Frontiers in Bioengineering and Biotechnology. https://doi.org/10.3389/fbioe.2022.838732 March 2022

Transporter-driven Engineering of a Genetic Biosensor for the Detection and Production of Short-branched Chain Fatty Acids in Saccharomyces cerevisiae

Miyake R, Ling H, Foo JL, Fugono N, Chang MW

Frontiers in Bioengineering and Biotechnology. https://doi.org/10.3389/fbioe.2022.838732 March 2022

Synthetic Biology: At the Crossroads of Genetic Engineering and Human Therapeutics-A Keystone Symposia Report
Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernandez LA, Lora JM, Kaufman HL, Quintana FJ, Geiger R, Lesser CF, Lunch JP, Hava DL, Cornish VW, Lee GK, DiAndreth B, Fero M, Srivastava R, Coster TD, Roybal KT, Rackham OJL, Kiani S, Zhu I, Hernandez-Lopez RA, Guo T, Chen WCW

Annals of the New York Academy of Sciences. https://doi.org/10.1111/nyas.14710 November 2021

A Newly Established Virus Induced Gene Silencing via Seed Imbibition for Functional Genomics at the Early Germination Stages in Cotton
Shi G, Hao M, Tian B, Cao G, Chen W, Zhang Q, Zhang Y, Ling H, Li J, Xie Z, Wei F

Industrial Crops and Products. https://doi.org/10.1016/j.indcrop.2021.114040 November 2021

Get in Touch!

We are excited to work with brilliant minds beaming with fresh ideas and insights into the curious natural world we live in. If you care about this planet and want to make a difference to it, then please don’t hesitate to get in touch with us for exciting opportunities in Chang Lab.