+65 6601 2449 [email protected]

Publications

Publications

Research Publications

2022
    1. Mitochondrial engineering of Yarrowia lipolytica for sustainable production of α-bisabolene from waste cooking oil
      Zhu K, Zhao B, Zhang Y, Kong J, Rong L, Liu S, Wang Y, Zhang C-Y, Xiao D, Foo JL, Yu A
      ACS Sustainable Chemistry and Engineering 10(29): 9644-9653 (2022)
    2. Synthetic biology for the sustainable production of biochemicals in engineered microbes
      Shi S, Wang J, Ling H
      Frontiers in Bioengineering and Biotechnology 10: 984875 (2022)
    3. Principles in microbiome engineering
      Chang MW
      Wiley-VCH GmbH (2022)
    4. Dominant negative TRAF3 variant with recurrent Mycobacterium abscessus infection and bronchiectasis
      Liew MF, Lim HF, Liang MC, Lim I, Tan Z, Tan RYM, Sam QH, Soe WM, Tay SH, Xu S, Chang MW*, Foo R, Soong TW, Ravikumar S, Chai LYA
      Open Forum Infectious Diseases 9(8): ofac379 (2022)
    5. Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism
      Koh E, Hwang IY, Lee HL, De Sotto R, Lee JWJ, Lee YS, March JC, Chang MW*
      Nature Communications 13: 3834 (2022)
    6. Engineered microbial systems for advanced drug delivery
      Shen HS, Aggarwal N, Wun KS, Lee YS, Hwang IY, Chang MW*
      Advanced Drug Delivery Reviews: 114364 (2022)
    7. Potential use of microbial engineering in single-cell protein production
      Balagurunathan B, Ling H, Choi WJ, Chang MW*
      Current Opinion in Biotechnology 76: 102740 (2022)
    8. Design and fabrication of field-deployable microbial biosensing device
      Pham HL, Ling H, Chang MW*
      Current Opinion in Biotechnology 76: 102731 (2022)
    9. Living building blocks
      Wun KS, Hwang IY, Chang MW*
      Nature Materials 21 (4): 382-383
    10. Transporter-driven engineering of a genetic biosensor for the detection and production of short-branched chain fatty acids in Saccharomyces cerevisiae
      Miyake R, Ling H, Foo JL, Fugono N, Chang MW*
      Frontiers in Bioengineering and Biotechnology (2022) In press
2021
    1. Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report
      Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernandez LA, Lora JM, Kaufman HL, Quintana FJ, Geiger R, Lesser CF, Lunch JP, Hava DL, Cornish VW, Lee GK, DiAndreth B, Fero M, Srivastava R, Coster TD, Roybal KT, Rackham OJL, Kiani S, Zhu I, Hernandez-Lopez RA, Guo T, Chen WCW
      Annals of the New York Academy of Sciences. 1506(1): 98-117 (2021)
    2. A newly established virus induced gene silencing via seed imbibition for functional genomics at the early germination stages in cotton
      Shi G, Hao M, Tian B, Cao G, Chen W, Zhang Q, Zhang Y, Ling H, Li J, Xie Z, Wei F
      Industrial Crops and Products. 172:114040 (2021)
    3. Driving innovation in biotechnology with private-public partnerships: a Singapore perspective
      Lee HL, Vasitvas K
      Biotechnology Notes 2: 59-62 (2021)
    4. Metabolic engineering of microbes for monoterpenoid production
      Zhu K, Kong J, Zhao B, Rong L, Liu S, Lu Z, Zhang C, Xiao D, Pushpanathan K, Foo JL, Wong A, Yu A.
      Biotechnology Advances 53: 107837 (2021)
    5. Hybrid promoter engineering strategies in Yarrowia lipolytica: isoamyl alcohol production as a test study
      Zhao Y, Liu S, Lu L, Zhao B, Wang S, Zhang C, Xiao D, Foo JL, Yu A
      Biotechnology for Biofuels 14: 149 (2021)
    6. Simultaneous improvement of limonene production and tolerance in Yarrowia lipolytica through tolerance engineering and evolutionary engineering
      Li J, Zhu K, Miao M, Rong L, Zhao Y, Li S, Ma L, Li J, Zhang C, Xiao D, Foo JL, Yu A
      ACS Synthetic Biology 10(4): 884-896 (2021)
    7. Next-generation metabolic engineering of non-conventional microbial cell factories for carboxylic acid platform chemicals
      Li J, Rong L, Zhao Y, Li S, Zhang C, Xiao D, Foo JL, Yu A
      Biotechnology Advances 43: 107605 (2020)
    8. Ectopic overexpression of a cotton plastidial Na+ transporter GhBASS5 impairs salt tolerance in Arabidopsis via increasing Na+ loading and accumulation
      Myo T, Tian B, Zhang Q, Niu S, Liu Z, Shi Y, Cao G, Ling H, Wei F, Shi G
      Planta 252(3): 41 (2020)
    9. Heterologous expression of cyanobacterial gas vesicle proteins in Saccharomyces cerevisiae
      Jung H, Ling H, Tan YQ, Chua NH, Yew WS, Chang MW
      Biotechnology Journal. 9: e2100059 (2021)
    10. Engineered probiotics modulate the endocannabinoid system
      Hwang IY, Kim HR, De Sotto R, Chang MW
      Biotechnology Notes 2: 33-38 (2021)
    11. The divergent immunomodulatory effects of short chain fatty acids and medium chain fatty acids
      Sam QH, Ling H, Yew WS, Tan Z, Ravikumar S, Chang MW, Chai LYA
      International Journal of Molecular Sciences 22(12): 6453 (2021)
    12. Future trends in synthetic biology in Asia
      Mao N, Aggarwal N, Poh CL, Cho BK, Kondo A, Liu C, Yew WS, Chang MW
      Advanced Genetics 2: e1003 (2021)
    13. Development of a polymer-based antimicrobial coating for efficacious urinary catheter protection
      Low JL, Kao P H-N, Tambyah PA, Koh GLE, Ling H, Kline KA, Cheow WS, Leong SSL
      Biotechnology Notes 2: 1-10 (2021)
    14. Biosynthesis of commodity chemicals from oil palm empty fruit bunch lignin
      Lo T-M, Hwang IY, Cho H-S, Fedora RE, Chng SH, Choi WJ, and Chang MW
      Frontiers in Microbiology 12: 663642 (2021)
2020
    1. Tweak to Treat: Reprograming Bacteria for Cancer Treatment
      Sieow BFL, Wun KS, Yong WP, Hwang IY, Chang MW
      Trends in Cancer, 7(5): 447-464 (2020).
    2. Genetic biosensor design for natural product biosynthesis in microorganisms
      Hossain GS, Saini M, Miyake R, Ling H, Chang MW
      Trends in Biotechnology. 38 (7): 797-810 (2020)
    3. Engineering probiotics for therapeutic applications: recent examples and translational outlook
      Aggarwal N, Breedon A, Davis C, Hwang IY, Chang MW
      Current Opinion in Biotechnology. 65: 171-179 (2020)
    4. Mechanism-Driven Metabolic Engineering for Bio-Based Production of Free R-Lipoic Acid in Saccharomyces cerevisiae Mitochondria
      Chen B, Foo JL, Ling H, Chang MW
      Frontiers in Bioengineering and Biotechnology. 8: 965 (2020). doi.org/10.3389/fbioe.2020.00965
    5. Engineering an Alcohol-Forming Fatty Acyl-CoA Reductase for Aldehyde and Hydrocarbon Biosynthesis in Saccharomyces cerevisiae
      Foo J L, Rasouliha B H, Susanto A V, Leong S S J and Chan M W
      Frontiers in Bioengineering and Biotechnology. 8: 585935 (2020). doi.org/10.3389/fbioe.2020.585935
    6. Development of a proline-based selection system for reliable genetic engineering in Chinese Hamster Ovary Cells
      Sun T, Kwok WC, Chua KJ, Lo T-M, Potter J, Yew WS, Chesnut JD, Hwang IY, and Chang MW
      ACS Synthetic Biology. (2020) (In press)
    7. Toolkit development for cyanogenic and gold biorecovery chassis Chromobacterium violaceum
      Liow LT, Go MK, Chang MW, Yew WS
      ACS Synthetic Biology. 2020, 9, 4, 953-961 (2020)
    8. Engineering Yarrowia lipolytica towards food waste bioremediation: Production of fatty acid ethyl esters from vegetable cooking oil
      Ng TK, Yu AQ, Ling H, Juwono NK, Choi WJ, Leong SS, Chang MW
      Journal of Bioscience and Bioengineering. 129(1): 31-40 (2020)
2019
    1. Engineering commensal bacteria to rewire host-microbiome interactions
      Hwang IY, Chang MW
      Current Opinion in Biotechnology 62:116-122 (2019)
    2. Phage-boosted chemotherapy
      Aggarwal N, Hwang IY, Chang MW
      Nature biomedical engineering 3(9):680-681 (2019)
    3. A novel synchronization approach using synthetic magnetic Escherichia coli
      Ling H, Chang MW
      Synthetic and Systems Biotechnology. 4(3):130-1 (2019)
    4. Meta-omics-and metabolic modelling-assisted deciphering of human microbiota metabolism
      Sieow BF, Nurminen TJ, Ling H, Chang MW
      Biotechnology journal. 30:1800445 (2019)
    5. Building a global alliance of biofoundries
      Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS
      Nat Communications. 10(1):2040 (2019)
    6. Synthetic genetic circuits for programmable biological functionalities
      Xia PF, Ling H, Foo JL, Chang MW
      Biotechnol Advances pii: S0734-9750(19)30074-6 (2019)
    7. Synthetic Biology Toolkits for Metabolic Engineering of Cyanobacteria
      Xia PF, Ling H, Foo JL, Chang MW
      Biotechnol Journal. e1800496. (2019)
2018
    1. An oleaginous yeast platform for renewable 1-butanol synthesis based on a heterologous CoA-dependent pathway and an endogenous pathway
      Yu A, Zhao Y, Pang Y, Hu Z, Zhang C, Xiao D, Chang MW, Leong SSJ
      Microb Cell Fact 17(1):166 (2018)
    2. Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity
      Lim YP, Go MK, Raida M, Inoue T, Wenk MR, Keasling JD, Chang MW, Yew WS
      ACS Omega 3(9):11050-11061 (2018))
    3. Genetically Engineered Bacteria as Vehicles for Localized Delivery of Therapeutics: An Application for Crohn’s Disease
      McKay R, Ghodasra M, Schardt K, Quan D, Pottash A, Shang W, Jay S, Payne G, Chang M, March J, Bentley W
      Bioengineering & Translational Medicine 3(3) (2018)
    4. Synthetic biology toolkits and applications in Saccharomyces cerevisiae
      Chen B, Lee HL, Heng YC, Chua N, Teo WS, Choi WJ, Leong SS, Foo JL, Chang MW
      Biotechnology Advances 36(7):1870-1881 (2018)
    5. Immunomodulation as Therapy for Fungal Infection: Are We Closer?
      Sam QH, Yew WS, Seneviratne CJ, Chang MW, Chai LYA
      Frontiers in Microbiology 9(1612) (2018)
    6. Targeted approaches for in situ gut microbiome manipulation
      Lee HL, Shen H, Hwang IY, Ling H, Yew WS, Lee YS, Chang MW
      Genes 9:351 (2018)
    7. Synthetic yeast genome reveals its versatility
      Foo JL, Chang MW
      Nature 557:647-648 (2018)
    8. Engineering microbes for targeted strikes against human pathogens
      Hwang IY, Lee HL, Huang JG, Lim YY, Yew WS, Lee YS, Chang MW
      Cellular and Molecular Life Sciences 75:2719-2733 (2018)
    9. Anhydrous polymer‐based coating with sustainable controlled release functionality for facile, efficacious impregnation, and delivery of antimicrobial peptides
      Lim K, Saravanan R, Chong KKL, Goh SHM, Chua RRY, Tambyah PA, Chang MW, Kline KA, Leong SSJ
      Biotechnology and Bioengineering 115:2000-2012 (2018)
    10. Reprogramming probiotic Lactobacillus reuteri as a biosensor for Staphylococcus aureus derived AIP-I detection
      Lubkowicz D, Ho CL, Hwang IY, Yew WS, Lee YS, Chang MW
      ACS Synthetic Biology 7(5):1229-1237 (2018)
    11. Rewriting the Metabolic Blueprint: Advances in Pathway Diversification in Microorganisms
      Hossain GS, Nadarajan SP, Zhang L, Ng TK, Foo JL, Ling H, Choi WJ, Chang MW
      Frontiers in Microbiology 9:155 (2018)
    12. Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention
      Ho CL, Tan HQ, Chua KJ, Kang A, Lim KH, Ling KL, Yew WS, Lee YS, Thiery JP, Chang MW
      Nature Biomedical Engineering 2:27–37 (2018)
2017
    1. Microscale Bioreactors for in situ characterization of GI epithelial cell physiology
      Costello C, Philipson M, Hartmanis L, Kwasnica M, Chen V, Hackam D, Chang MW, Bentley W, March J
      Scientific Reports 7:12515 (2017)
    2. Autoinducer sensing microarrays by reporter bacteria encapsulated in hybrid supramolecular-polysaccharide hydrogels
      Li P, Dou XO, Müller M, Feng C, Chang MW, Frettlöh M, Schönherr H
      Macromolecular Bioscience. 1700176:8-16 (2017)
    3. Encapsulation of Autoinducer Sensing Reporter Bacteria in Reinforced Alginate-based Microbeads
      Li P, Müller M, Chang MW, Frettlöh M, Schönherr H
      ACS Appl Mater Interfaces. 9(27):22321–22331 (2017)
    4. Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes
      Pham HL, Wong A, Chua N, Teo WS, Yew WS, and Chang MW
      Nature Communications. 8:411 (2017)
    5. Isolated Reporter Bacteria in Supramolecular Hydrogel Microwell Arrays
      Li P, Dou XQ, Feng C, Müller M, Chang MW, Frettlöh M, Schönherr H
      Langmuir. 33 (31):7799–7809 (2017)
    6. Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
      Hwang IY, Koh E, Wong A, March JC, Bentley WE, Lee YS, and Chang MW
      Nature Communications. 8:15028 (2017)
    7. Designer probiotics for the prevention and treatment of human diseases
      Chua KJ, Kwok WC, Aggarwal N, Sun T, and Chang MW
      Current Opinion in Chemical Biology. 40:8-16 (2017)
    8. Applying the design-build-test paradigm in microbiome engineering
      Pham HL, Ho CL, Wong A, Lee YS, and Chang MW
      Current Opinion in Biotechnology. 48:85–93 (2017)
    9. The Fungal Mycobiome and Its Interaction with Gut Bacteria in the Host
      Sam QH, Chang MW, and Chai LYA
      International Journal of Molecular Sciences. 18, 330 (2017)
    10. Microbiome engineering: Current applications and its future
      Foo JL, Ling H, Lee YS, and Chang MW
      Biotechnology Journal. 2, 1600099 (2017)
2016
    1. Synthetic Biology in Asia: New Kids on the Block
      Chang MW
      ACS Synthetic Biology. 10.1021/acssynbio.6b00327 (2016)
    2. Genetic Engineering of an Unconventional Yeast for Renewable Biofuel and Biochemical Production
      Yu A, Pratomo NK, Ng TK, Ling H, Cho HS, Leong S, Chang MW
      Journal of Visualized Experiments. doi:10.3791/54371 (2016)
    3. Reprogrammable microbial cell-based therapeutics againstantibiotic-resistant bacteria
      Hwang IY, Koh E, Kima HR, Yew WS, Chang MW
      Drug Resistance Updates. 27 59–71 (2016)
    4. A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production
      Lo T, Chng SH, Teo WS, Cho HS, Chang MW
      Cell Systems. 3:133-143. (2016)
    5. Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids
      Yu A, Pratomo NK, Foo JL, Leong SSJ, Chang MW
      Metabolic Engineering. 34:36-43. (2016)
    6. Whole-cell biocatalytic and de novo production of alkanes from free fatty acids in Saccharomyces cerevisiae
      Foo JL, Susanto AV, Keasling JD, Leong SSJ, Chang MW
      Biotechnology and Bioengineering. 114:232-237. (2016)
2015
    1. Engineering transcription factors to improve tolerance against alkane biofuels in Saccharomyces cerevisiae
      Ling H, Pratomo NK, Teo WS, Liu R, Leong SSJ, Chang MW
      Biotechnology for Biofuels. 8:231. (2015)
    2. Combinatorial metabolic engineering of Saccharomyces cerevisiae for terminal alkene production
      Chen BB, Lee DY, Chang MW
      Metabolic Engineering. 31:53-61. (2015)
    3. Engineering Saccharomyces cerevisiae to produce odd chain-length fatty alcohols
      Jin Z, Wong CK, Foo JL, Ng J, Cao YX, Chang MW, Yuan YJ
      Biotechnology and Bioengineering. 113:842-51. (2015)
    4. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel
      Teo W, Ling H, Yu AQ, Chang MW
      Biotechnology for Biofuels. 8:177. (2015)
    5. Matrix-immobilized yeast for large-scale production of recombinant human lactoferrin
      Ho CL, Hwang IY, Loh K and Chang MW
      MedChemComm. 6:486 – 491. (2015)
    6. Bacterial XylRs and synthetic promoters function as genetically encoded xylose biosensors in Saccharomyces cerevisiae
      Teo W and Chang MW
      Biotechnology Journal. 10:315-322. (2015)
2014
    1. Production of fatty acid-derived valuable chemicals in synthetic microbes
      Yu AQ, Pratomo Juwono NK, Leong SSJ and Chang MW
      Frontiers in Bioengineering and Biotechnology. 2:78 (2014)
    2. Microbial tolerance engineering toward biochemical production: from lignocellulose to products
      Ling H, Teo W, Chen B, Leong SSJ, Chang MW
      Current Opinion in Biotechnology. 29:99-106. (2014)
    3. Site specific immobilization of a potent antimicrobial peptide onto silicone catheters: evaluation against urinary tract infection pathogens
      Mishra B, Basu A, Chua RRY, Saravanan R, Tambyah PA, Ho B, Chang MW, Leong SSJ
      Journal of Materials Chemistry. 2:1706-1716. (2014)
    4. Reprogramming microbes to be a pathogen-seeking killer
      Hwang IY, Tan MH, Koh E, Ho CL, Poh CL, and Chang MW
      ACS Synthetic Biology. 3:228-237. (2014)
      Featured in The Economist, Nature News, Medical News, Science World Report, Science Daily, Vaccine News Daily, Food Quality News, MedCity News; Press release by American Chemical Society
    5. Development and characterization of AND-gate dynamic controllers with a modular synthetic core promoter in Saccharomyces cerevisiae
      Teo W, Chang MW
      Biotechnology and Bioengineering. 111:144-151. (2014)
    6. Therapeutic microbes for infectious disease
      Wong CK, Tan MH, Rasouliha B, Hwang IY, Ling H, Poh CL and Chang MW
      Methods in Molecular Biology. 1151:117-133. (2014)
2013
    1. A predicted immunity protein confers resistance to pyocin S5 on a sensitive strain of Pseudomonas aeruginosa
      Rasouliha B, Ling H, Ho CL, Chang MW
      ChemBioChem. 14:2444-2446.47. (2013)
    2. Transcriptome response to alkane biofuels in Saccharomyces cerevisiae: identification of efflux pumps involved in alkane tolerance
      Ling H, Chen BB, Kang A, Lee J, Chang MW
      Biotechnology for Biofuels. 6:95. (2013)
      Featured in Biofuels International
    3. Bacterial FadR and synthetic promoters function as modular fatty acid sensor- regulators in Saccharomyces cerevisiae
      Teo W, Hee KS, Chang MW
      Engineering in Life Sciences. 13:456-463. (2013)
    4. Designing a synthetic genetic circuit that enables cell density-dependent auto-regulatory lysis for macromolecule release
      Lo T, Tan MH, Hwang IY, Chang MW
      Chemical Engineering Science. 103:29-35. (2013)
    5. Microbial engineering strategies to improve cell viability for biochemical production
      Lo T, Teo WS, Ling H, Chen BB, Kang A, Chang MW
      Biotechnology Advances. 31:903-914. (2013)
    6. Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae
      Chen BB, Ling H, Chang MW
      Biotechnology for Biofuels. 6:21. (2013)
      Featured in the Global Knowledge Center on Crop Biotechnology
    7. Characterization of a quorum sensing device for synthetic biology design: experimental and modeling validation
      Saeidi N, Chang MW, and Poh CL
      Chemical Engineering Science. 103:91-99. (2013)
    8. Systems-level characterization and engineering of oxidative stress tolerance in Escherichia coli under anaerobic condition
      Kang A, Tan MH, Ling H, Chang MW
      Molecular BioSystems. 9:285-295. (2013)
2012
    1. Hildebrand solubility parameters of ionic liquids: effects of ionic liquid type, temperature and DMA fraction in ionic liquid
      Weerachanchai P, Chen Z, Leong SSJ, Chang MW, Lee JM
      Chemical Engineering Journal. 213:356-362. (2012)
    2. Cefalexin-immobilized multi-walled carbon nanotubes show strong antimicrobial and anti-adhesion properties
      Qi X, Poernomo G, Xu R, Chang MW
      Chemical Engineering Science. 84:552-556. (2012)
    3. Systems-level analysis of Escherichia coli response to silver nanoparticles: The roles of anaerobic respiration in microbial resistance
      Du H, Lo T, Sitompul J, and Chang MW
      Biochemical and Biophysical Research Communications. 424:657-662. (2012)
    4. Improvement of biomass properties by pretreatment with ionic liquids for bioconversion process
      Weerachanchai P, Leong SSJ, Chang MW, Ching CB, Lee JM
      Bioresource Technology. 111:453-459. (2012)
    5. Identification and reconstitution of genetic regulatory networks for improved microbial tolerance to isooctane
      Kang A, Chang MW
      Molecular BioSystems. 8:1350-1358. (2012)
    6. The imminent role of protein engineering in synthetic biology
      Foo JL, Ching CB, Chang MW, Leong SSJ
      Biotechnology Advances. 30:541-549. (2012)
2011
    1. Hollow fiber membrane decorated with Ag/MWNTs: Towards effective water disinfection and biofouling control
      Gunawan P, Guan C, Song X; Zhang Q, Leong S, Tang C, Chen Y, Chan-Park M, Chang MW, Wang K, Xu R
      ACS Nano. 5:10033-10040. (2011)
    2. The roles of lipid in anti-biofilm efficacy of lipid–polymer hybrid nanoparticles encapsulating antibiotics
      Cheow WS, Chang MW, Hadinoto K
      Colloids and Surfaces A: Physicochemical and Engineering Aspects. 389: 158-165. (2011)
    3. Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen
      Saeidi N, Wong CK, Lo T, Nguyen HX, Ling H, Leong SSJ, Poh CL, and Chang MW
      Molecular Systems Biology. 7:521. (2011)
      Highlighted in Nature Reviews Genetics 9:699, and Nature Reviews Microbiology 12:668.
      This paper was reported by over 70 news media agencies worldwide, such as Reuters, CBS News, Fox News, Chicago Tribune, Australia Broadcasting Corporation News, Nature, Science, Yahoo News, The Scientist, Discover Magazine, International Business Times, and National Geographic. Locally, this work has been selected as one of the top 10 discoveries in 2011 by Straits Times, and featured by most local news agencies including Channel News Asia.
    4. Covalent immobilization of nisin on multi-walled carbon nanotubes: superior antimicrobial and anti-biofilm properties
      Qi X, Poernomo G, Wang K, Chen Y, Chan-Park MB, Xu R, Chang MW
      Nanoscale. 3:1874-1880. (2011)
    5. Targeting FK506 binding proteins to fight malarial and bacterial infections: Current advances and future perspectives
      Bharatham N, Chang MW, Yoon HS
      Current Medicinal Chemistry. 18:1874-1889. (2011)
    6. A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine
      Zhou C, Peng L, Qi X, Lamrani M, Chang MW, Leong SS, Chan-Park MB
      Biomaterials. 32:2704-2712. (2011)
    7. A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability
      Li P, Poon YF, Li W, Zhu HY, Yeap SH, Cao Y, Qi X, Zhou C, Lamrani M, Beuerman RW, Kang ET, Mu Y, Li CM, Chang MW, Leong SS, and Chan-Park MB
      Nature Materials. 10:149-156. (2011)
2010
    1. Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells
      Choi YH, Park CH, Kim W, Ling H, Kang A, Chang MW, Im SK, Jeong HW, Kong YY, Kim KT
      PLoS One. 5:e15254. (2010)
    2. The absence of the luxS gene increases swimming motility and flagella synthesis in Escherichia coli K12
      Ling H, Kang A, Tan MH, Qiao B, and Chang MW
      Biochemical and Biophysical Research Communications. 401:521-526. (2010)
    3. A simple and effective plating method to screen polycyclic aromatic hydrocarbon-degrading bacteria under various redox conditions
      Um Y, Chang MW, and Holoman TP
      Applied Microbiology and Biotechnology. 88:291-297. (2010)
    4. iTRAQ-coupled 2-D LC-MS/MS analysis of protein profile in Escherichia coli incubated with human Neutrophil Peptide 1 – Potential in Antimicrobial Strategy
      Zhou Y, Lamrani M, Chan-Park MB, Leong S, Chang MW, and Chen WN
      Rapid Communications in Mass Spectrometry. 24:2787-2790. (2010)
    5. Novel short antibacterial and antifungal peptides with low cytotoxicity: efficacy and action mechanisms
      Qi X, Zhou C, Li P, Xu W, Cao Y, Ling H, Chen WN, Li CM, Xu R, Lamrani M, Mu Y, Leong S, Chang MW, and Chan-Park MB
      Biochemical and Biophysical Research Communications. 398:594-600. (2010)
    6. Antibacterial efficacy of inhalable Levofloxacin-loaded polymeric nanoparticles against E. coli biofilm cells: The effect of antibiotic release profile
      Cheow WS, Chang MW, Hadinoto K
      Pharmaceutical Research. 27:1597-1609. (2010)
    7. A predicted S-type pyocin shows a bactericidal activity against clinical Pseudomonas aeruginosa isolates through membrane damage
      Ling H, Saedi N, Rasouliha BH, and Chang MW
      FEBS Letters. 584:3354-3358. (2010)
    8. High potency and broad-spectrum antimicrobial peptides synthesized via ring-opening polymerization of alpha-aminoacid-N-carboxyanhydrides
      Zhou C, Qi X, Li P, Chen WN, Lamrani M, Chang MW, Leong S and Chan-Park MB
      Biomacromolecules. 11:60-67. (2010)
    9. Antibacterial efficacy of inhalable antibiotic-encapsulated biodegradable polymeric nanoparticles against E. coli biofilm cells
      Cheow WS, Chang MW, and Hadinoto K.
      Journal of Biomedical Nanotechnology. 6:1-13. (2010)
2009
    1. Sharper and faster “Nano Darts” kill more bacteria: a study of antibacterial activity of individually dispersed pristine single-walled carbon nanotube
      Liu S, Wei L, Hao L, Fang N, Chang MW, Xu R, Yang Y, and Chen Y
      ACS Nano. 3:3891-3902. (2009)
    2. A time-course transcriptome analysis of Escherichia coli with direct electrochemistry behavior in microbial fuel cells
      Qiao Y, Li CM, Lu Z, Ling H, Kang A and Chang MW
      Chemical Communications 41:6183-6185 (2009)
    3. Strain improvement and process development for biobutanol production
      Kharkwal S, Karimi IA, Chang MW, and Lee DY
      Recent Patents on Biotechnology 3:202-210. (2009)
2008
    1. Deposition of Silver Nanoparticles on Multiwalled Carbon Nanotubes Grafted with Hyperbranched Poly(amidoamine) and Their Antimicrobial Effects
      Yuan W, Jiang G, Jianfei C, Xiaobao Q, Xu R, Chang MW, Chen Y, Lim SY, Dai J, and Chan-Park MB
      Journal of Physical Chemistry C 112:18754-18759. (2008)
    2. Molecular characterization of surfactant-driven microbial community changes in anaerobic phenanthrene-degrading cultures under methanogenic conditions
      Chang MW, Holoman TP, and Yi H
      Biotechnology Letters 30:1595-1601. (2008)
    3. Microarray analysis of toxicogenomic effects of triclosan on Staphylococcus aureus
      Jang H, Chang MW, Toghrol F, and Bentley WE
      Applied Microbiology and Biotechnology 78:695-707. (2008)
2007
    1. Toxicogenomic response to chlorination includes induction of major virulence genes in Staphylococcus aureus
      Chang MW, Toghrol F, and Bentley WE
      Environmental Science and Technology 41:7570-7575. (2007)
    2. Comparative global transcription analysis of sodium hypochlorite, peracetic acid, and hydrogen peroxide in Pseudomonas aeruginosa
      Small D, Chang MW, Toghrol F, and Bentley WE
      Applied Microbiology and Biotechnology 76:1093-1105. (2007)
    3. Toxicogenomic analysis of sodium hypochlorite antimicrobial mechanisms in Pseudomonas aeruginosa
      Small D, Chang MW, Toghrol F, and Bentley WE
      Applied Microbiology and Biotechnology 74:176-185. (2007)
2006
    1. Toxicogenomic response of Staphylococcus aureus to peracetic acid
      Chang MW, Toghrol F, and Bentley WE
      Environmental Science and Technology 40:5124-5131. (2006)
    2. Polycyclic aromatic hydrocarbon (PAH) degradation coupled to methanogenesis
      Chang MW, Um Y, and Holoman TP
      Biotechnology Letters 28:425-430. (2006)
    3. Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide
      Chang MW, Small D, Toghrol F, and Bentley WE
      Journal of Bacteriology 184:1648-1659. (2006).
2005
    1. Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide
      Chang MW, Small D, Toghrol F, and Bentley WE
      BMC Genomics 6:115. (2005)
    2. Microarray analysis of toxicogenomic effects of peracetic acid on Pseudomonas aeruginosa
      Chang MW, Small D, Toghrol F, and Bentley WE
      Environmental Science and Technology 39:5893-5899. (2005)
    3. Molecular characterization of anaerobic microbial communities from benzene-degrading sediments under methanogenic conditions
      Chang MW, Um Y, and Holoman TP
      Biotechnology Progress 21:1789-1794. (2005)
    4. Molecular characterization of polycyclic aromatic hydrocarbon (PAH)-degrading methanogenic communities
      Chang MW, Um Y, Hoffman B, and Holoman TP
      Biotechnology Progress 21:682-688. (2005)
2001
  1. Anaerobic polycyclic aromatic hydrocarbon (PAH)-degrading enrichment cultures under methanogenic conditions
    Chang MW, Jones T, and Holoman TP
    Bioremediation of Recalcitrant Organic Compounds, Battelle Press, Columbus, Ohio. p. 205-210. (2001)
  1. Mitochondrial engineering of Yarrowia lipolytica for sustainable production of α-bisabolene from waste cooking oil
    Zhu K, Zhao B, Zhang Y, Kong J, Rong L, Liu S, Wang Y, Zhang C-Y, Xiao D, Foo JL, Yu A
    ACS Sustainable Chemistry and Engineering 10(29): 9644-9653 (2022)
  2. Synthetic biology for the sustainable production of biochemicals in engineered microbes
    Shi S, Wang J, Ling H
    Frontiers in Bioengineering and Biotechnology 10: 984875 (2022)
  3. Principles in microbiome engineering
    Chang MW
    Wiley-VCH GmbH (2022)
  4. Dominant negative TRAF3 variant with recurrent Mycobacterium abscessus infection and bronchiectasis
    Liew MF, Lim HF, Liang MC, Lim I, Tan Z, Tan RYM, Sam QH, Soe WM, Tay SH, Xu S, Chang MW*, Foo R, Soong TW, Ravikumar S, Chai LYA
    Open Forum Infectious Diseases 9(8): ofac379 (2022)
  5. Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism
    Koh E, Hwang IY, Lee HL, De Sotto R, Lee JWJ, Lee YS, March JC, Chang MW*
    Nature Communications 13: 3834 (2022)
  6. Engineered microbial systems for advanced drug delivery
    Shen HS, Aggarwal N, Wun KS, Lee YS, Hwang IY, Chang MW*
    Advanced Drug Delivery Reviews: 114364 (2022)
  7. Potential use of microbial engineering in single-cell protein production
    Balagurunathan B, Ling H, Choi WJ, Chang MW*
    Current Opinion in Biotechnology 76: 102740 (2022)
  8. Design and fabrication of field-deployable microbial biosensing device
    Pham HL, Ling H, Chang MW*
    Current Opinion in Biotechnology 76: 102731 (2022)
  9. Living building blocks
    Wun KS, Hwang IY, Chang MW*
    Nature Materials 21 (4): 382-383
  10. Transporter-driven engineering of a genetic biosensor for the detection and production of short-branched chain fatty acids in Saccharomyces cerevisiae
    Miyake R, Ling H, Foo JL, Fugono N, Chang MW*
    Frontiers in Bioengineering and Biotechnology (2022) In press
  1. Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report
    Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernandez LA, Lora JM, Kaufman HL, Quintana FJ, Geiger R, Lesser CF, Lunch JP, Hava DL, Cornish VW, Lee GK, DiAndreth B, Fero M, Srivastava R, Coster TD, Roybal KT, Rackham OJL, Kiani S, Zhu I, Hernandez-Lopez RA, Guo T, Chen WCW
    Annals of the New York Academy of Sciences. 1506(1): 98-117 (2021)
  2. A newly established virus induced gene silencing via seed imbibition for functional genomics at the early germination stages in cotton
    Shi G, Hao M, Tian B, Cao G, Chen W, Zhang Q, Zhang Y, Ling H, Li J, Xie Z, Wei F
    Industrial Crops and Products. 172:114040 (2021)
  3. Driving innovation in biotechnology with private-public partnerships: a Singapore perspective
    Lee HL, Vasitvas K
    Biotechnology Notes 2: 59-62 (2021)
  4. Metabolic engineering of microbes for monoterpenoid production
    Zhu K, Kong J, Zhao B, Rong L, Liu S, Lu Z, Zhang C, Xiao D, Pushpanathan K, Foo JL, Wong A, Yu A.
    Biotechnology Advances 53: 107837 (2021)
  5. Hybrid promoter engineering strategies in Yarrowia lipolytica: isoamyl alcohol production as a test study
    Zhao Y, Liu S, Lu L, Zhao B, Wang S, Zhang C, Xiao D, Foo JL, Yu A
    Biotechnology for Biofuels 14: 149 (2021)
  6. Simultaneous improvement of limonene production and tolerance in Yarrowia lipolytica through tolerance engineering and evolutionary engineering
    Li J, Zhu K, Miao M, Rong L, Zhao Y, Li S, Ma L, Li J, Zhang C, Xiao D, Foo JL, Yu A
    ACS Synthetic Biology 10(4): 884-896 (2021)
  7. Heterologous expression of cyanobacterial gas vesicle proteins in Saccharomyces cerevisiae
    Jung H, Ling H, Tan YQ, Chua NH, Yew WS, Chang MW
    Biotechnology Journal. 9: e2100059 (2021)
  8. Engineered probiotics modulate the endocannabinoid system
    Hwang IY, Kim HR, De Sotto R, Chang MW
    Biotechnology Notes 2: 33-38 (2021)
  9. The divergent immunomodulatory effects of short chain fatty acids and medium chain fatty acids
    Sam QH, Ling H, Yew WS, Tan Z, Ravikumar S, Chang MW, Chai LYA
    International Journal of Molecular Sciences 22(12): 6453 (2021)
  10. Future trends in synthetic biology in Asia
    Mao N, Aggarwal N, Poh CL, Cho BK, Kondo A, Liu C, Yew WS, Chang MW
    Advanced Genetics 2: e1003 (2021)
  11. Development of a polymer-based antimicrobial coating for efficacious urinary catheter protection
    Low JL, Kao P H-N, Tambyah PA, Koh GLE, Ling H, Kline KA, Cheow WS, Leong SSL
    Biotechnology Notes 2: 1-10 (2021)
  12. Biosynthesis of commodity chemicals from oil palm empty fruit bunch lignin
    Lo T-M, Hwang IY, Cho H-S, Fedora RE, Chng SH, Choi WJ, and Chang MW
    Frontiers in Microbiology 12: 663642 (2021)
  1. Next-generation metabolic engineering of non-conventional microbial cell factories for carboxylic acid platform chemicals
    Li J, Rong L, Zhao Y, Li S, Zhang C, Xiao D, Foo JL, Yu A
    Biotechnology Advances 43: 107605 (2020)
  2. Ectopic overexpression of a cotton plastidial Na+ transporter GhBASS5 impairs salt tolerance in Arabidopsis via increasing Na+ loading and accumulation
    Myo T, Tian B, Zhang Q, Niu S, Liu Z, Shi Y, Cao G, Ling H, Wei F, Shi G
    Planta 252(3): 41 (2020)
  3. Tweak to Treat: Reprograming Bacteria for Cancer Treatment
    Sieow BFL, Wun KS, Yong WP, Hwang IY, Chang MW
    Trends in Cancer, 7(5): 447-464 (2020).
  4. Genetic biosensor design for natural product biosynthesis in microorganisms
    Hossain GS, Saini M, Miyake R, Ling H, Chang MW
    Trends in Biotechnology. 38 (7): 797-810 (2020)
  5. Engineering probiotics for therapeutic applications: recent examples and translational outlook
    Aggarwal N, Breedon A, Davis C, Hwang IY, Chang MW
    Current Opinion in Biotechnology. 65: 171-179 (2020)
  6. Mechanism-Driven Metabolic Engineering for Bio-Based Production of Free R-Lipoic Acid in Saccharomyces cerevisiae Mitochondria
    Chen B, Foo JL, Ling H, Chang MW
    Frontiers in Bioengineering and Biotechnology. 8: 965 (2020)
  7. Engineering an Alcohol-Forming Fatty Acyl-CoA Reductase for Aldehyde and Hydrocarbon Biosynthesis in Saccharomyces cerevisiae
    Foo J L, Rasouliha B H, Susanto A V, Leong S S J and Chan M W
    Frontiers in Bioengineering and Biotechnology. 8: 585935 (2020)
  8. Development of a proline-based selection system for reliable genetic engineering in Chinese Hamster Ovary Cells
    Sun T, Kwok WC, Chua KJ, Lo T-M, Potter J, Yew WS, Chesnut JD, Hwang IY, and Chang MW
    ACS Synthetic Biology. (2020) (In press)
  9. Toolkit development for cyanogenic and gold biorecovery chassis Chromobacterium violaceum
    Liow LT, Go MK, Chang MW, Yew WS
    ACS Synthetic Biology. 2020, 9, 4, 953-961 (2020)
  10. Engineering Yarrowia lipolytica towards food waste bioremediation: Production of fatty acid ethyl esters from vegetable cooking oil
    Ng TK, Yu AQ, Ling H, Juwono NK, Choi WJ, Leong SS, Chang MW
    Journal of Bioscience and Bioengineering. 129(1): 31-40 (2020)
  1. Engineering commensal bacteria to rewire host-microbiome interactions
    Hwang IY, Chang MW
    Current Opinion in Biotechnology 62:116-122 (2019)
  2. Phage-boosted chemotherapy
    Aggarwal N, Hwang IY, Chang MW
    Nature biomedical engineering 3(9):680-681 (2019)
  3. A novel synchronization approach using synthetic magnetic Escherichia coli
    Ling H, Chang MW
    Synthetic and Systems Biotechnology. 4(3):130-1 (2019)
  4. Meta-omics-and metabolic modelling-assisted deciphering of human microbiota metabolism
    Sieow BF, Nurminen TJ, Ling H, Chang MW
    Biotechnology journal. 30:1800445 (2019)
  5. Building a global alliance of biofoundries
    Hillson N, Caddick M, Cai Y, Carrasco JA, Chang MW, Curach NC, Bell DJ, Le Feuvre R, Friedman DC, Fu X, Gold ND, Herrgård MJ, Holowko MB, Johnson JR, Johnson RA, Keasling JD, Kitney RI, Kondo A, Liu C, Martin VJJ, Menolascina F, Ogino C, Patron NJ, Pavan M, Poh CL, Pretorius IS, Rosser SJ, Scrutton NS, Storch M, Tekotte H, Travnik E, Vickers CE, Yew WS, Yuan Y, Zhao H, Freemont PS
    Nat Communications. 10(1):2040 (2019)
  6. Synthetic genetic circuits for programmable biological functionalities
    Xia PF, Ling H, Foo JL, Chang MW
    Biotechnol Advances pii: S0734-9750(19)30074-6 (2019)
  7. Synthetic Biology Toolkits for Metabolic Engineering of Cyanobacteria
    Xia PF, Ling H, Foo JL, Chang MW
    Biotechnol Journal. e1800496. (2019)
  1. An oleaginous yeast platform for renewable 1-butanol synthesis based on a heterologous CoA-dependent pathway and an endogenous pathway
    Yu A, Zhao Y, Pang Y, Hu Z, Zhang C, Xiao D, Chang MW, Leong SSJ
    Microb Cell Fact 17(1):166 (2018)
  2. Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity
    Lim YP, Go MK, Raida M, Inoue T, Wenk MR, Keasling JD, Chang MW, Yew WS
    ACS Omega 3(9):11050-11061 (2018))
  3. Genetically Engineered Bacteria as Vehicles for Localized Delivery of Therapeutics: An Application for Crohn’s Disease
    McKay R, Ghodasra M, Schardt K, Quan D, Pottash A, Shang W, Jay S, Payne G, Chang M, March J, Bentley W
    Bioengineering & Translational Medicine 3(3) (2018)
  4. Synthetic biology toolkits and applications in Saccharomyces cerevisiae
    Chen B, Lee HL, Heng YC, Chua N, Teo WS, Choi WJ, Leong SS, Foo JL, Chang MW
    Biotechnology Advances 36(7):1870-1881 (2018)
  5. Immunomodulation as Therapy for Fungal Infection: Are We Closer?
    Sam QH, Yew WS, Seneviratne CJ, Chang MW, Chai LYA
    Frontiers in Microbiology 9(1612) (2018)
  6. Targeted approaches for in situ gut microbiome manipulation
    Lee HL, Shen H, Hwang IY, Ling H, Yew WS, Lee YS, Chang MW
    Genes 9:351 (2018)
  7. Synthetic yeast genome reveals its versatility
    Foo JL, Chang MW
    Nature 557:647-648 (2018)
  8. Engineering microbes for targeted strikes against human pathogens
    Hwang IY, Lee HL, Huang JG, Lim YY, Yew WS, Lee YS, Chang MW
    Cellular and Molecular Life Sciences 75:2719-2733 (2018)
  9. Anhydrous polymer‐based coating with sustainable controlled release functionality for facile, efficacious impregnation, and delivery of antimicrobial peptides
    Lim K, Saravanan R, Chong KKL, Goh SHM, Chua RRY, Tambyah PA, Chang MW, Kline KA, Leong SSJ
    Biotechnology and Bioengineering 115:2000-2012 (2018)
  10. Reprogramming probiotic Lactobacillus reuteri as a biosensor for Staphylococcus aureus derived AIP-I detection
    Lubkowicz D, Ho CL, Hwang IY, Yew WS, Lee YS, Chang MW
    ACS Synthetic Biology 7(5):1229-1237 (2018)
  11. Rewriting the Metabolic Blueprint: Advances in Pathway Diversification in Microorganisms
    Hossain GS, Nadarajan SP, Zhang L, Ng TK, Foo JL, Ling H, Choi WJ, Chang MW
    Frontiers in Microbiology 9:155 (2018)
  12. Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention
    Ho CL, Tan HQ, Chua KJ, Kang A, Lim KH, Ling KL, Yew WS, Lee YS, Thiery JP, Chang MW
    Nature Biomedical Engineering 2:27–37 (2018)
  1. Microscale Bioreactors for in situ characterization of GI epithelial cell physiology
    Costello C, Philipson M, Hartmanis L, Kwasnica M, Chen V, Hackam D, Chang MW, Bentley W, March J
    Scientific Reports 7:12515 (2017)
  2. Autoinducer sensing microarrays by reporter bacteria encapsulated in hybrid supramolecular-polysaccharide hydrogels
    Li P, Dou XO, Müller M, Feng C, Chang MW, Frettlöh M, Schönherr H
    Macromolecular Bioscience. 1700176:8-16 (2017)
  3. Encapsulation of Autoinducer Sensing Reporter Bacteria in Reinforced Alginate-based Microbeads
    Li P, Müller M, Chang MW, Frettlöh M, Schönherr H
    ACS Appl Mater Interfaces. 9(27):22321–22331 (2017)
  4. Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes
    Pham HL, Wong A, Chua N, Teo WS, Yew WS, and Chang MW
    Nature Communications. 8:411 (2017)
  5. Isolated Reporter Bacteria in Supramolecular Hydrogel Microwell Arrays
    Li P, Dou XQ, Feng C, Müller M, Chang MW, Frettlöh M, Schönherr H
    Langmuir. 33 (31):7799–7809 (2017)
  6. Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
    Hwang IY, Koh E, Wong A, March JC, Bentley WE, Lee YS, and Chang MW
    Nature Communications. 8:15028 (2017)
  7. Designer probiotics for the prevention and treatment of human diseases
    Chua KJ, Kwok WC, Aggarwal N, Sun T, and Chang MW
    Current Opinion in Chemical Biology. 40:8-16 (2017)
  8. Applying the design-build-test paradigm in microbiome engineering
    Pham HL, Ho CL, Wong A, Lee YS, and Chang MW
    Current Opinion in Biotechnology. 48:85–93 (2017)
  9. The Fungal Mycobiome and Its Interaction with Gut Bacteria in the Host
    Sam QH, Chang MW, and Chai LYA
    International Journal of Molecular Sciences. 18, 330 (2017)
  10. Microbiome engineering: Current applications and its future
    Foo JL, Ling H, Lee YS, and Chang MW
    Biotechnology Journal. 2, 1600099 (2017)
  1. Synthetic Biology in Asia: New Kids on the Block
    Chang MW
    ACS Synthetic Biology. 10.1021/acssynbio.6b00327 (2016)
  2. Genetic Engineering of an Unconventional Yeast for Renewable Biofuel and Biochemical Production
    Yu A, Pratomo NK, Ng TK, Ling H, Cho HS, Leong S, Chang MW
    Journal of Visualized Experiments. doi:10.3791/54371 (2016)
  3. Reprogrammable microbial cell-based therapeutics againstantibiotic-resistant bacteria
    Hwang IY, Koh E, Kima HR, Yew WS, Chang MW
    Drug Resistance Updates. 27 59–71 (2016)
  4. A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production
    Lo T, Chng SH, Teo WS, Cho HS, Chang MW
    Cell Systems. 3:133-143. (2016)
  5. Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids
    Yu A, Pratomo NK, Foo JL, Leong SSJ, Chang MW
    Metabolic Engineering. 34:36-43. (2016)
  6. Whole-cell biocatalytic and de novo production of alkanes from free fatty acids in Saccharomyces cerevisiae
    Foo JL, Susanto AV, Keasling JD, Leong SSJ, Chang MW
    Biotechnology and Bioengineering. 114:232-237. (2016)
  1. Engineering transcription factors to improve tolerance against alkane biofuels in Saccharomyces cerevisiae
    Ling H, Pratomo NK, Teo WS, Liu R, Leong SSJ, Chang MW
    Biotechnology for Biofuels. 8:231. (2015)
  2. Combinatorial metabolic engineering of Saccharomyces cerevisiae for terminal alkene production
    Chen BB, Lee DY, Chang MW
    Metabolic Engineering. 31:53-61. (2015)
  3. Engineering Saccharomyces cerevisiae to produce odd chain-length fatty alcohols
    Jin Z, Wong CK, Foo JL, Ng J, Cao YX, Chang MW, Yuan YJ
    Biotechnology and Bioengineering. 113:842-51. (2015)
  4. Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid short- and branched-chain alkyl esters biodiesel
    Teo W, Ling H, Yu AQ, Chang MW
    Biotechnology for Biofuels. 8:177. (2015)
  5. Matrix-immobilized yeast for large-scale production of recombinant human lactoferrin
    Ho CL, Hwang IY, Loh K and Chang MW
    MedChemComm. 6:486 – 491. (2015)
  6. Bacterial XylRs and synthetic promoters function as genetically encoded xylose biosensors in Saccharomyces cerevisiae
    Teo W and Chang MW
    Biotechnology Journal. 10:315-322. (2015)
  1. Production of fatty acid-derived valuable chemicals in synthetic microbes
    Yu AQ, Pratomo Juwono NK, Leong SSJ and Chang MW
    Frontiers in Bioengineering and Biotechnology. 2:78 (2014)
  2. Microbial tolerance engineering toward biochemical production: from lignocellulose to products
    Ling H, Teo W, Chen B, Leong SSJ, Chang MW
    Current Opinion in Biotechnology. 29:99-106. (2014)
  3. Site specific immobilization of a potent antimicrobial peptide onto silicone catheters: evaluation against urinary tract infection pathogens
    Mishra B, Basu A, Chua RRY, Saravanan R, Tambyah PA, Ho B, Chang MW, Leong SSJ
    Journal of Materials Chemistry. 2:1706-1716. (2014)
  4. Reprogramming microbes to be a pathogen-seeking killer
    Hwang IY, Tan MH, Koh E, Ho CL, Poh CL, and Chang MW
    ACS Synthetic Biology. 3:228-237. (2014)
    Featured in The Economist, Nature News, Medical News, Science World Report, Science Daily, Vaccine News Daily, Food Quality News, MedCity News; Press release by American Chemical Society
  5. Development and characterization of AND-gate dynamic controllers with a modular synthetic core promoter in Saccharomyces cerevisiae
    Teo W, Chang MW
    Biotechnology and Bioengineering. 111:144-151. (2014)
  6. Therapeutic microbes for infectious disease
    Wong CK, Tan MH, Rasouliha B, Hwang IY, Ling H, Poh CL and Chang MW
    Methods in Molecular Biology. 1151:117-133. (2014)
  1. A predicted immunity protein confers resistance to pyocin S5 on a sensitive strain of Pseudomonas aeruginosa
    Rasouliha B, Ling H, Ho CL, Chang MW
    ChemBioChem. 14:2444-2446.47. (2013)
  2. Transcriptome response to alkane biofuels in Saccharomyces cerevisiae: identification of efflux pumps involved in alkane tolerance
    Ling H, Chen BB, Kang A, Lee J, Chang MW
    Biotechnology for Biofuels. 6:95. (2013)
    Featured in Biofuels International
  3. Bacterial FadR and synthetic promoters function as modular fatty acid sensor- regulators in Saccharomyces cerevisiae
    Teo W, Hee KS, Chang MW
    Engineering in Life Sciences. 13:456-463. (2013)
  4. Designing a synthetic genetic circuit that enables cell density-dependent auto-regulatory lysis for macromolecule release
    Lo T, Tan MH, Hwang IY, Chang MW
    Chemical Engineering Science. 103:29-35. (2013)
  5. Microbial engineering strategies to improve cell viability for biochemical production
    Lo T, Teo WS, Ling H, Chen BB, Kang A, Chang MW
    Biotechnology Advances. 31:903-914. (2013)
  6. Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae
    Chen BB, Ling H, Chang MW
    Biotechnology for Biofuels. 6:21. (2013)
    Featured in the Global Knowledge Center on Crop Biotechnology
  7. Characterization of a quorum sensing device for synthetic biology design: experimental and modeling validation
    Saeidi N, Chang MW, and Poh CL
    Chemical Engineering Science. 103:91-99. (2013)
  8. Systems-level characterization and engineering of oxidative stress tolerance in Escherichia coli under anaerobic condition
    Kang A, Tan MH, Ling H, Chang MW
    Molecular BioSystems. 9:285-295. (2013)
  1. Hildebrand solubility parameters of ionic liquids: effects of ionic liquid type, temperature and DMA fraction in ionic liquid
    Weerachanchai P, Chen Z, Leong SSJ, Chang MW, Lee JM
    Chemical Engineering Journal. 213:356-362. (2012)
  2. Cefalexin-immobilized multi-walled carbon nanotubes show strong antimicrobial and anti-adhesion properties
    Qi X, Poernomo G, Xu R, Chang MW
    Chemical Engineering Science. 84:552-556. (2012)
  3. Systems-level analysis of Escherichia coli response to silver nanoparticles: The roles of anaerobic respiration in microbial resistance
    Du H, Lo T, Sitompul J, and Chang MW
    Biochemical and Biophysical Research Communications. 424:657-662. (2012)
  4. Improvement of biomass properties by pretreatment with ionic liquids for bioconversion process
    Weerachanchai P, Leong SSJ, Chang MW, Ching CB, Lee JM
    Bioresource Technology. 111:453-459. (2012)
  5. Identification and reconstitution of genetic regulatory networks for improved microbial tolerance to isooctane
    Kang A, Chang MW
    Molecular BioSystems. 8:1350-1358. (2012)
  6. The imminent role of protein engineering in synthetic biology
    Foo JL, Ching CB, Chang MW, Leong SSJ
    Biotechnology Advances. 30:541-549. (2012)
  7. Hollow fiber membrane decorated with Ag/MWNTs: Towards effective water disinfection and biofouling control
    Gunawan P, Guan C, Song X; Zhang Q, Leong S, Tang C, Chen Y, Chan-Park M, Chang MW, Wang K, Xu R
    ACS Nano. 5:10033-10040. (2011)
  8. The roles of lipid in anti-biofilm efficacy of lipid–polymer hybrid nanoparticles encapsulating antibiotics
    Cheow WS, Chang MW, Hadinoto K
    Colloids and Surfaces A: Physicochemical and Engineering Aspects. 389: 158-165. (2011)
  9. Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen
    Saeidi N, Wong CK, Lo T, Nguyen HX, Ling H, Leong SSJ, Poh CL, and Chang MW
    Molecular Systems Biology. 7:521. (2011)
    Highlighted in Nature Reviews Genetics 9:699, and Nature Reviews Microbiology 12:668.
    This paper was reported by over 70 news media agencies worldwide, such as Reuters, CBS News, Fox News, Chicago Tribune, Australia Broadcasting Corporation News, Nature, Science, Yahoo News, The Scientist, Discover Magazine, International Business Times, and National Geographic. Locally, this work has been selected as one of the top 10 discoveries in 2011 by Straits Times, and featured by most local news agencies including Channel News Asia.
  10. Covalent immobilization of nisin on multi-walled carbon nanotubes: superior antimicrobial and anti-biofilm properties
    Qi X, Poernomo G, Wang K, Chen Y, Chan-Park MB, Xu R, Chang MW
    Nanoscale. 3:1874-1880. (2011)
  11. Targeting FK506 binding proteins to fight malarial and bacterial infections: Current advances and future perspectives
    Bharatham N, Chang MW, Yoon HS
    Current Medicinal Chemistry. 18:1874-1889. (2011)
  12. A photopolymerized antimicrobial hydrogel coating derived from epsilon-poly-l-lysine
    Zhou C, Peng L, Qi X, Lamrani M, Chang MW, Leong SS, Chan-Park MB
    Biomaterials. 32:2704-2712. (2011)
  13. A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability
    Li P, Poon YF, Li W, Zhu HY, Yeap SH, Cao Y, Qi X, Zhou C, Lamrani M, Beuerman RW, Kang ET, Mu Y, Li CM, Chang MW, Leong SS, and Chan-Park MB
    Nature Materials. 10:149-156. (2011)
  14. Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells
    Choi YH, Park CH, Kim W, Ling H, Kang A, Chang MW, Im SK, Jeong HW, Kong YY, Kim KT
    PLoS One. 5:e15254. (2010)
  15. The absence of the luxS gene increases swimming motility and flagella synthesis in Escherichia coli K12
    Ling H, Kang A, Tan MH, Qiao B, and Chang MW
    Biochemical and Biophysical Research Communications. 401:521-526. (2010)
  16. A simple and effective plating method to screen polycyclic aromatic hydrocarbon-degrading bacteria under various redox conditions
    Um Y, Chang MW, and Holoman TP
    Applied Microbiology and Biotechnology. 88:291-297. (2010)
  17. iTRAQ-coupled 2-D LC-MS/MS analysis of protein profile in Escherichia coli incubated with human Neutrophil Peptide 1 – Potential in Antimicrobial Strategy
    Zhou Y, Lamrani M, Chan-Park MB, Leong S, Chang MW, and Chen WN
    Rapid Communications in Mass Spectrometry. 24:2787-2790. (2010)
  18. Novel short antibacterial and antifungal peptides with low cytotoxicity: efficacy and action mechanisms
    Qi X, Zhou C, Li P, Xu W, Cao Y, Ling H, Chen WN, Li CM, Xu R, Lamrani M, Mu Y, Leong S, Chang MW, and Chan-Park MB
    Biochemical and Biophysical Research Communications. 398:594-600. (2010)
  19. Antibacterial efficacy of inhalable Levofloxacin-loaded polymeric nanoparticles against E. coli biofilm cells: The effect of antibiotic release profile
    Cheow WS, Chang MW, Hadinoto K
    Pharmaceutical Research. 27:1597-1609. (2010)
  20. A predicted S-type pyocin shows a bactericidal activity against clinical Pseudomonas aeruginosa isolates through membrane damage
    Ling H, Saedi N, Rasouliha BH, and Chang MW
    FEBS Letters. 584:3354-3358. (2010)
  21. High potency and broad-spectrum antimicrobial peptides synthesized via ring-opening polymerization of alpha-aminoacid-N-carboxyanhydrides
    Zhou C, Qi X, Li P, Chen WN, Lamrani M, Chang MW, Leong S and Chan-Park MB
    Biomacromolecules. 11:60-67. (2010)
  22. Antibacterial efficacy of inhalable antibiotic-encapsulated biodegradable polymeric nanoparticles against E. coli biofilm cells
    Cheow WS, Chang MW, and Hadinoto K.
    Journal of Biomedical Nanotechnology. 6:1-13. (2010)
  23. Sharper and faster “Nano Darts” kill more bacteria: a study of antibacterial activity of individually dispersed pristine single-walled carbon nanotube
    Liu S, Wei L, Hao L, Fang N, Chang MW, Xu R, Yang Y, and Chen Y
    ACS Nano. 3:3891-3902. (2009)
  24. A time-course transcriptome analysis of Escherichia coli with direct electrochemistry behavior in microbial fuel cells
    Qiao Y, Li CM, Lu Z, Ling H, Kang A and Chang MW
    Chemical Communications 41:6183-6185 (2009)
  25. Strain improvement and process development for biobutanol production
    Kharkwal S, Karimi IA, Chang MW, and Lee DY
    Recent Patents on Biotechnology 3:202-210. (2009)
  26. Deposition of Silver Nanoparticles on Multiwalled Carbon Nanotubes Grafted with Hyperbranched Poly(amidoamine) and Their Antimicrobial Effects
    Yuan W, Jiang G, Jianfei C, Xiaobao Q, Xu R, Chang MW, Chen Y, Lim SY, Dai J, and Chan-Park MB
    Journal of Physical Chemistry C 112:18754-18759. (2008)
  27. Molecular characterization of surfactant-driven microbial community changes in anaerobic phenanthrene-degrading cultures under methanogenic conditions
    Chang MW, Holoman TP, and Yi H
    Biotechnology Letters 30:1595-1601. (2008)
  28. Microarray analysis of toxicogenomic effects of triclosan on Staphylococcus aureus
    Jang H, Chang MW, Toghrol F, and Bentley WE
    Applied Microbiology and Biotechnology 78:695-707. (2008)
  29. Toxicogenomic response to chlorination includes induction of major virulence genes in Staphylococcus aureus
    Chang MW, Toghrol F, and Bentley WE
    Environmental Science and Technology 41:7570-7575. (2007)
  30. Comparative global transcription analysis of sodium hypochlorite, peracetic acid, and hydrogen peroxide in Pseudomonas aeruginosa
    Small D, Chang MW, Toghrol F, and Bentley WE
    Applied Microbiology and Biotechnology 76:1093-1105. (2007)
  31. Toxicogenomic analysis of sodium hypochlorite antimicrobial mechanisms in Pseudomonas aeruginosa
    Small D, Chang MW, Toghrol F, and Bentley WE
    Applied Microbiology and Biotechnology 74:176-185. (2007)
  32. Toxicogenomic response of Staphylococcus aureus to peracetic acid
    Chang MW, Toghrol F, and Bentley WE
    Environmental Science and Technology 40:5124-5131. (2006)
  33. Polycyclic aromatic hydrocarbon (PAH) degradation coupled to methanogenesis
    Chang MW, Um Y, and Holoman TP
    Biotechnology Letters 28:425-430. (2006)
  34. Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide
    Chang MW, Small D, Toghrol F, and Bentley WE
    Journal of Bacteriology 184:1648-1659. (2006).
  35. Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide
    Chang MW, Small D, Toghrol F, and Bentley WE
    BMC Genomics 6:115. (2005)
  36. Microarray analysis of toxicogenomic effects of peracetic acid on Pseudomonas aeruginosa
    Chang MW, Small D, Toghrol F, and Bentley WE
    Environmental Science and Technology 39:5893-5899. (2005)
  37. Molecular characterization of anaerobic microbial communities from benzene-degrading sediments under methanogenic conditions
    Chang MW, Um Y, and Holoman TP
    Biotechnology Progress 21:1789-1794. (2005)
  38. Molecular characterization of polycyclic aromatic hydrocarbon (PAH)-degrading methanogenic communities
    Chang MW, Um Y, Hoffman B, and Holoman TP
    Biotechnology Progress 21:682-688. (2005)
  39. Anaerobic polycyclic aromatic hydrocarbon (PAH)-degrading enrichment cultures under methanogenic conditions
    Chang MW, Jones T, and Holoman TP
    Bioremediation of Recalcitrant Organic Compounds, Battelle Press, Columbus, Ohio. p. 205-210. (2001)